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Electronic Cigarette Clinical Trials

 Over the last four years more and more people have started using electronic nicotine delivery devices called ‘e cigarettes’. These electronic cigarettes or 'ecigs' deliver nicotine into the body using the traditional method of tobacco smoking which is inhalation but without any of the harmful side effects.

As more and more tobacco smokers are switching over to the electric cigarette concerns have been raised as to their safety. Is the electric cigarette a safe method of delivering nicotine than tobacco? So far there have been several studies and tests which indicate that electric cigarettes are indeed a lot safer than tobacco.

List of Electronic Cigarette Clinical Trials & Studies

The University of Auckland

To measure the short-term effects of an electronic nicotine delivery device ("e cigarette", ENDD) on desire to smoke, withdrawal symptoms, acceptability, pharmacokinetic properties and adverse effects. The electronic cigarette alleviated desire to smoke after overnight abstinence, was well tolerated and had a pharmacokinetic profile more like the Nicorette inhalator than a tobacco cigarette. View clinical study details... 

Onassis Cardiac Surgery Center, Kallithea, Greece

Smoking one tobacco cigarette led to acute, significant impairment of four parameters of left ventricular function, but electronic cigarettes had no acute adverse effects. Smoking tobacco cigarettes also led to significant elevations in blood pressure and heart rate (+8% systolic BP, +6% diastolic BP, and a 10% rise in heart rate) compared with a single elevation of around 4% in diastolic BP in the electronic-cigarette users.Farsalinos says e-cigarettes address both sides of a smoker's addiction: the chemical craving for nicotine, which has known effects on the brain, "and the psychological/behavioral addiction that comes from having something in your hand, lighting it up, seeing smoke, and inhaling and exhaling it." Read about this study... 

U.S. National Institutes of Health
The study's major aim is to investigate the ability of a commercial Electronic Nicotine Delivery Device (E-Cigarette) to induce long-term smoking reduction/abstinence in smokers unwilling to quit. Secondary aims are to investigate changes in withdrawal symptoms and cravings and to examine whether concomitant use of the E-Cigarette and smoking is safe. The study will monitor smoking reduction/abstinence effects, changes in withdrawal symptoms, and adverse events of a currently marketed device in Italy ("Categoria" electronic cigarette - "ORIGINAL" 7.2 mg nicotine cartridges). The primary hypothesis is that the E-Cigarette is a safe device that allows smoking reduction or abstinence in smokers possibly by suppressing withdrawal symptoms and cravings. View actual trial details... 

New Zealand Clinical Trial

One of the most famous e cigarette and e-liquid clinical trials conducted was performed by Dr Murray Laugson atHealth new Zealand. These clinical trials found that the e-liquid used in the electric delivery device (ecig) was not harmful if used properly. The New Zealand Ministry of Health advise New Zealand Parliament that E Cigarettes are a lot safer than smoking tobacco. 

BioMed Central Clinical Trial

Biomed Central conducted a clinical study on 40 confirmed tobacco smokers who had no intention of quitting smoking, the study showed that within 4 weeks the confirmed tobacco smokers had reduced the amount of tobacco cigarettes they normally smoked by 50%! The end result of the study showed that “The use of e-Cigarettes substantially decreased tobacco cigarette consumption without causing significant side effects in smokers not intending to quit”. If you would like to view the actual trial study paper click here

Virginia Commonwealth University & National Cancer Institute (NCI) Clinical Study

The Virginia Commonwealth University and National Cancer Institute (NCI) both sponsored a clinical study into the use of the electric cigarette. The purpose of this particular study was to develop a 'Clinical Model' that could be used to determine the effectiveness of electric cigarette nicotine delivery devices for aiding tobacco smokers to stop smoking. The actual study compared the nicotine delivery, cardiovascular effects, and tobacco withdrawal suppressing effects of e cigarettes.

American Journal Preventive Medicine Clinical Study

A study conducted by the American Journal of Preventive Medicine, the clinical study which was to “examine the effectiveness of e-cigarettes for smoking cessation…” . In this study a high number of tobacco smokers were tested, they were given an electric cigarette to use, the study showed that over 50% had completely given up smoking tobacco cigarettes at the end of the trial. This study finally concluded that "electric cigarettes may have a high degree of success when its comes to tobacco smoking cessation".

WSMI Position Paper on Electronic Nicotine Delivery Systems

The WSMI (World Self Medication Industry) produced an official paper stating its stance on electric cigarettes and electronic nicotine delivery systems. The WSMI stated that there was a lack of legislation regarding electronic devices and it raised concerns about devices that could encourage nicotine addiction instead of cessation. It should be noted however that the WSMI is the leading organization for NRT (Nicotine Replacement) products and the use of electric cigarettes could be seen to have a direct effect on their own product ranges.

Department of Political Science, University of California /
Department of Community Health Sciences, Boston University School of Public Health

Zachary Cahn and Michael Siegel of the above institutions wrote a in-depth paper on the study of tobacco smoking and electric cigarette usage and the impact of electronic cigarettes on the cessation of tobacco smoking. The study went deeply into the tobacco industry, nicotine addiction and electric cigarettes, at the end of the study both writers concluded after much research that “electronic cigarettes are a much safer alternative to tobacco cigarettes”.

British Psychological Society

The British Psychological Society has released a report stating that while electronic cigarettes may help people to quit smoking tobacco – they may also help improve peoples memory! The study showed that “the e-cigarette with nicotine helped men more than women in terms of reducing their craving. A research report released at the British Psychological Society's Annual Conference 18th-20th April 2012 by Dr Lynne Dawkins of the University of East London stated that eCigarettes may improve mood and memory.


Boston University School of Public Health E Cigarette Research Study

Boston University School of Public Health (BUSPH) performed an e cigarette research study into the effectiveness of electronic cigarettes as a smoking-cessation tool. Boston University School of Public Health was founded in 1976 and is a leading educational and public health research institution. "This study suggests that electronic cigarettes are helping thousands of ex-smokers remain off cigarettes," said lead author Michael Siegel, professor of community health sciences.

American Association of Public Health Physicians E Cigarette Statement

In April 2010 the American Association of Public Health Physicians (AAPHP) which was founded in 1954 and as an organisation its initial purpose was to serve as the voice of physician directors of state and local health departments at the national level has published its approval for the sale of e cigarettes to adults. AAPHP stated “AAPHP favors a permissive approach to E-cigarettes because the possibility exists to save the lives of four million of the eight million current adult American smokers who will otherwise die of a tobacco-related illness over the next twenty years".

So Are Electronic Cigarettes Safe? 
The above are only a small amount of clinical trials and studies conducted so far, there are still some concerns about the whether electronic cigarettes are safe or not. Some say yes and some say no, some people say they still have a health effect and others say they don’t. 

Even with the trials so far it can be confusing to know what is the truth and what is not, and I guess at the end of the day you have to choose for yourself. One fact stands out in all studies, trials and communications between the ‘for’ and ‘against’ and that is that BOTH sides agree that electronic nicotine delivery devices (e cigarettes) are a LOT safer for you than smoking tobacco cigarettes. 


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